It can't always be smooth sailing for characters. There are times when the water is a little rougher than readers can handle. But does that mean writers should avoid uncomfortable topics?
If you're familiar with my writing, you already know that I hardly write about princesses and unicorns. It's not unusual for me to touch on some uncomfortable topics. Not to suggest there haven't been some that gave me a moment of pause, but in the end, I had to follow the story, and more importantly, follow the character and their journey.
Not to say that it's easy.
It's also possible that your readers may complain about where the story sometimes goes, especially when things get dark. The truth is that for many people, reality gets pretty dark sometimes and for a group of characters to avoid this is simply unrealistic, especially when involved in a long-running series.
In the end, you have to follow the story wherever it takes you. I think a character that experiences some extreme highs and lows, creates compassion from the reader while giving characters more dimension. We connect more with people (in both reality and fiction) if we see they've been through some soul-searching moments in their lives because we relate to it ourselves.